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Targeting ovarian solid tumors by Elastin-like polypeptide drug conjugates: Current trends and future prospectives

Author(s):

Deepthi Ramamurthi, Moola Joghee Nanjan Chandrasekar*, Shanthi Bhupathi Santhosh and Sunil Kumar Patnaik  

Abstract:


Background: Ovarian cancer is one of the leading causes of death worldwide. Polymers have low cytotoxicity and high functional ability and hence used for drug delivery systems, tissue engineering, and polymer therapeutics. In drug delivery systems, polymer-drug conjugates have shown considerable promise, especially in anticancer chemotherapy.

Objective: Anticancer drug delivery systems (DDS) deliver drugs to the tumor site, leading to reduced exposure to healthy cells and reduced side effects. Efforts have been made to develop effective DDS using stimuli-responsive polymers like thermo sensitive and pH-sensitive polymers.

Conclusion: Elastin-like polypeptides (ELP), one of the thermoresponsive polymers, have been identified as drug carriers in anticancer therapy. ELP-drug conjugates have the potential and can be used effectively in combination with hyperthermia for targeting drugs to solid tumors. This review reports on the use of ELPs in cancer therapy, its biomedical applications, and recent developments to target medicines to solid ovarian tumors.

Keywords:

Ovarian cancer, elastin-like peptides, anticancer, therapy, chemotherapy, cytotoxicity

Affiliation:

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris, Tamilnadu, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris, Tamilnadu, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris, Tamilnadu, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris, Tamilnadu



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