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Micro-RNA, a promising biomarker for breast and ovarian cancer: A Review

Author(s):

Fatima Akram*, Noman Atique, Ikram ul Haq, Zeeshan Ahmed, Zuriat Jabbar, Ali Nawaz, Amna Aqeel and Rabia Akram  

Abstract:


Background: Micro-RNAs (miRNA) belong to the substantial class of post-transcriptional gene regulators with decisive functions in typical cellular and disease progressions. They are short RNA molecules that are not translated into proteins, bind to the complementary sites of various mRNAs, blocking them, and hence lead to translational inhibition.

Objective: These miRNA molecules act as signatory molecules or biomarkers for various types of malignancies. Different miRNAs are involved in different cancer-linked pathways depending on the nature, stage, and kind of cancer. The objective of this article is to discuss and review the role and significance of various miRNAs in two of the most prominent cancers; breast and ovarian cancer.

Methods: The role and participation of miRNAs in instigation, propagation, and metastasis of melanoma is elucidated.

Results: This article focuses on the up and downregulation of various miRNAs in breast and ovarian cancer, with stress on diversity in their occurrence and specificity in their threshold levels in certain types and stages of cancer, suggesting their potential role as an effective diagnostic and treatment tool for cancer.

Conclusion: Considering all the mentioned information, it can be concluded that mi-RNAs can act as potential biomarkers for the diagnosis of breast and ovarian cancers.

Keywords:

Biomarker; Cancer; Diagnosis; Translation; Inhibition; Gene regulation.

Affiliation:

Institute of Industrial Biotechnology, GC University, Lahore-54000, Institute of Industrial Biotechnology, GC University, Lahore-54000, Institute of Industrial Biotechnology, GC University, Lahore-54000, Institute of Industrial Biotechnology, GC University, Lahore-54000, Institute of Industrial Biotechnology, GC University, Lahore-54000, Institute of Industrial Biotechnology, GC University, Lahore-54000, Institute of Industrial Biotechnology, GC University, Lahore-54000, Institute of Industrial Biotechnology, GC University, Lahore-54000



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