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Ultrasound-triggered Immunotherapy for Cancer Treatment: An Update

Author(s):

Debasmita Mukhopadhyay, Amal Ahmed, Catherine Sano, Nahid Awad, Nour AlSawaftah and Ghaleb A Husseini*   Pages 1 - 12 ( 12 )

Abstract:


Over the past few decades, immunotherapy has emerged as a promising therapeutic approach to treat some types of cancer. Moreover, antibody-based cancer therapies can trigger apoptosis and cell growth inhibition to induce immune cell destruction of target cells through antibody-dependent cellular cytotoxicity (ADCC). Nevertheless, immunotherapeutic efficiency is often restricted to either deficient delivery or low accumulation of therapeutic molecules at the tumor site. Therefore, exposing immunoliposomes to ultrasound can effectively improve drug accessibility by enhancing cell membrane permeability and drug release. This review summarizes existing traditional cancer treatments and their limitations, emphasizing the recent advancements in ultrasound-triggered immunotherapy.

Keywords:

Ultrasound, immunotherapy, liposome, microbubbles, cancer, cell growth

Affiliation:

Chemical Engineering Department, American University of Sharjah, Sharjah, Chemical Engineering Department, American University of Sharjah, Sharjah, Chemical Engineering Department, University of Virginia, Charlottesville, VA, Chemical Engineering Department, American University of Sharjah, Sharjah, Chemical Engineering Department, American University of Sharjah, Sharjah, Chemical Engineering Department, American University of Sharjah, Sharjah



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