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Understanding The Role of Inflammasome in Angina Pectoris

[ Vol. 22 , Issue. 3 ]

Author(s):

Ishita Sharma, Tapan Behl*, Simona Bungau, Monika Sachdeva, Arun Kumar, Gokhan Zengin and Sandeep Arora   Pages 228 - 236 ( 9 )

Abstract:


Angina pectoris, associated with coronary artery disease, a cardiovascular disease where the pain is caused by adverse oxygen supply in the myocardium, results in contractility and discomfort in the chest. Inflammasomes, triggered by stimuli due to infection and cellular stress, have been identified to play a vital role in the progression of cardiovascular disorders and, thus, causing various symptoms like angina pectoris. Nlrp3 inflammasome, a key contributor in the pathogenesis of angina pectoris, requires activation and primary signaling for the commencement of inflammation. Nlrp3 inflammasome elicits out an inflammatory response by the emission of pro-inflammatory cytokines by ROS (reactive oxygen species) production, mobilization of K+ efflux and Ca2+ and by activation of lysosome destabilization that eventually causes pyroptosis, a programmed cell death process. Thus, inflammasome is considered to be one of the factors involved in the progression of coronary artery diseases and has an intricate role in the development of angina pectoris.

Keywords:

Angina pectoris, inflammasomes, Nlrp3 inflammasome, coronary artery disease, pyroptosis, cardiovascular disease.

Affiliation:

Chitkara College of Pharmacy, Chitkara University, Punjab, Chitkara College of Pharmacy, Chitkara University, Punjab, Department of Pharmacy, Faculty of Medicine of Pharmacy, University of Oradea, Oradea, Fatima College of Health Science, Al Ain, Chitkara College of Pharmacy, Chitkara University, Punjab, Department of Biology, Faculty of Science, University Campus, Konya, Chitkara College of Pharmacy, Chitkara University, Punjab

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