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Amino Acids Regulate Glycolipid Metabolism and Alter Intestinal Microbial Composition

[ Vol. 21 , Issue. 8 ]

Author(s):

Fei Xie, Zhengqun Liu, Ming Liu, Liang Chen, Wei Ding* and Hongfu Zhang*   Pages 761 - 765 ( 5 )

Abstract:


Amino acids (AAs) and their metabolites regulate key metabolic pathways that are necessary for growth, reproduction, immunity and metabolism of the body. It has been convinced that metabolic diseases are closely related to disorders of glycolipid metabolism. A growing number of studies have shown that AAs are closely related to energy metabolism. This review focuses on the effects of amino acids (arginine, branched-chain amino acids, glutamine) and their metabolites (short chain fatty acids) on glycolipid metabolism by regulating PI3K/AKT/mTOR and AMPK signaling pathways and GPCRs receptors, reducing intestinal Firmicutes/Bacteroidetes ratio associated with obesity.

Keywords:

Glycolipid metabolism, amino acids (AAs), short chain fatty acids (SCFAs), intestinal microbial composition, metabolic pathways, metabolites.

Affiliation:

State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, Department of Gerontology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193

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