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PlantPIs – An Interactive Web Resource on Plant Protease Inhibitors

[ Vol. 12 , Issue. 5 ]

Author(s):

Arianna Consiglio, Giorgio Grillo, Flavio Licciulli, Luigi R. Ceci, Sabino Liuni, Nicola Losito, Mariateresa Volpicella, Raffaele Gallerani and Francesca De Leo   Pages 448 - 454 ( 7 )

Abstract:


PlantPIs is a web querying system for a database collection of plant protease inhibitors data. Protease inhibitors in plants are naturally occurring proteins that inhibit the function of endogenous and exogenous proteases. In this paper the design and development of a web framework providing a clear and very flexible way of querying plant protease inhibitors data is reported. The web resource is based on a relational database, containing data of plants protease inhibitors publicly accessible, and a graphical user interface providing all the necessary browsing tools, including a data exporting function. PlantPIs contains information extracted principally from MEROPS database, filtered, annotated and compared with data stored in other protein and gene public databases, using both automated techniques and domain expert evaluations. The data are organized to allow a flexible and easy way to access stored information. The database is accessible at http://www.plantpis.ba.itb.cnr.it/.

Keywords:

Bioinformatics, database, Kingdom plantae, MEROPS, protease inhibitors, web querying system, anti-metabolic proteins, sequence homology, pseudo-substrates, syntactic control, Universal Protein Resource, hierarchical, NCBI, Domains, Taxonomies, ETL process

Affiliation:

Institute of Biomembranes and Bioenergetics IBBE, National Research Council CNR, Via Amendola 165/A, 70126 Bari Italy.



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