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Role of α6β4 Integrin in Cell Motility, Invasion and Metastasis of Mammary Tumors

[ Vol. 12 , Issue. 1 ]

Author(s):

Jun Chung, John L. Clifford, Young Hwa Soung and Hyea Jin Gil   Pages 23 - 29 ( 7 )

Abstract:


Integrin α6β4 is the receptor for the laminin family of extracellular matrix proteins and is widely expressed in most epithelial tissues and Schwann cells. The expression of this integrin is up-regulated in most epithelial tumors, suggesting the role of α6β4 in their progression. The tumor microenvironment is also known to enhance the signaling competence of α6β4 through functional and physical interactions with other receptors. In this review, we discuss the biological mechanisms by which integrin α6β4 promotes carcinoma cell motility and invasion that leads to mammary tumor progression.

Keywords:

metastasis, invasion, cell motility, carcinoma, Integrin α6β4

Affiliation:

Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Centerat Shreveport, 1501 Kings Highway, Shreveport, LA 71106, USA.



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