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Erbin, a Negative Regulator in Diverse Signal Pathways

[ Vol. 11 , Issue. 8 ]

Author(s):

Dan Liu, Ming Shi, Huijun Duan, Caili Han and Ning Guo   Pages 759 - 764 ( 6 )

Abstract:


Erbin belongs to the LAP protein family. Originally, Erbin was described as a Her2-interacting protein. Recent studies demonstrated that Erbin could inhibit the Ras-mediated activation of the mitogen-activated protein kinase (MAPK), nuclear factor-κB (NF-κB) and transforming growth factor β (TGF-β) signaling pathways. It suggests that Erbin may function as a signaling molecule. The functions of Erbin in determining cell polarity and cell adhesion have been well described. This review mainly focuses on the recent findings in regulation of signaling pathways by Erbin.

Keywords:

Erbin, MAPK, ERK, NF-κB, TGF-β, signal transduction, carbonyl termini, epithelial morphogensis, mutagenesis, velocardiofacial syndrome, down regulation

Affiliation:

Department of Molecular Immunology, Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, P.R. China and Department of Pathology, Hebei Medical University, Shijiazhuang 05007, P.R. China.



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