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The Fink Blueprint for Hsp70/Hsc70 Molecular Chaperones

[ Vol. 10 , Issue. 5 ]

Author(s):

Stephan N. Witt   Pages 424 - 431 ( 8 )

Abstract:


In a Nature article published in 1993, Anthony L. Fink and colleagues reported how Hsp70 chaperones use ATP binding in the presence of K+, rather than hydrolysis, to accelerate substrate release. As of the summer of 2008, his article had received 297 citations. I discuss here the influence Tonys iconic article has had on the chaperone field.

Keywords:

Chaperone, heat shock protein, unfolded protein, ATPase

Affiliation:

Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, USA.



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