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The Fink Blueprint for Hsp70/Hsc70 Molecular Chaperones

[ Vol. 10 , Issue. 5 ]


Stephan N. Witt   Pages 424 - 431 ( 8 )


In a Nature article published in 1993, Anthony L. Fink and colleagues reported how Hsp70 chaperones use ATP binding in the presence of K+, rather than hydrolysis, to accelerate substrate release. As of the summer of 2008, his article had received 297 citations. I discuss here the influence Tonys iconic article has had on the chaperone field.


Chaperone, heat shock protein, unfolded protein, ATPase


Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, USA.

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