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Crystallographic Cryoenzymology and the Legacy of Tony Fink

[ Vol. 10 , Issue. 5 ]


Gregory A. Petsko   Pages 416 - 423 ( 8 )


During the past thirty years significant contributions to our understanding of the structural origins of the catalytic power of enzymes have come from solution and crystallographic studies of enzyme-substrate and enzymeintermediate complexes trapped at subzero temperatures, a field that was pioneered in large part by Anthony L. Fink and Pierre Douzou. Here I review, from a personal perspective, the history of crystallographic cryoenzymology, with an emphasis on the contributions of Tony Fink. The story has a moral: if you choose your collaborators based not only on their scientific prowess but also on their human qualities, the resulting friendships will enrich your life.

, Crystallographic, Cryoenzymology, and, the, Legacy, of, Tony, Fink


Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South Street, Waltham, MA 02454-9110 USA.

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