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Structure and Function of Bacterial Initiation Factors

[ Vol. 3 , Issue. 1 ]


R. Boelens and C. O. Gualerzi   Pages 107 - 119 ( 13 )


Bacteria require three initiation factors, IF1, IF2 and IF3, to start protein synthesis. In the last few years the elucidation of both structural and mechanistic aspects pertaining to these proteins has made substantial progress. In this article we outline the translation initiation process in bacteria and review these recent developments giving a summary of the main features of the structure and function of the initiation factors.


protein synthesis, translation initiation process, initiatio factorif1, initiatio factorif2, initiatio factorif3, Topography


Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherland

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