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Lactoferrin as a potent natural supplement exhibiting a synergistic effect with drugs in antimicrobial and anticancer therapies

Author(s):

Przemysław Gajda-Morszewski and Małgorzata Brindell*  

Abstract:


For many years, natural products have played a crucial role in drug discovery and drug design as a source of active agents or as inspiration. Lactoferrin (Lf), a glycoprotein found in milk and mammalian secretions, has been extensively studied in recent years, and numerous antimicrobial, anti-inflammatory, and anticancer properties of Lf have been demonstrated in the literature. The use of lactoferrin as a co-agent or supplement to enhance the beneficial effect of drugs, or to reduce their side effects, arouses the interest of many researchers, especially since Lf is a well-studied, biocompatible, cheap, and easily accessible protein. In this mini-review, we focus on the elucidation of the role of Lf in antimicrobial or anticancer therapies, pointing to the possible mechanism underlying the determined synergism between Lf and commonly used drugs.

Keywords:

lactoferrin, synergism, antimicrobial, anticancer, mechanism of activity, modulation of iron accessibility, immunomodulation

Affiliation:

Department of Inorganic Chemistry, Faculty of Chemistry, Jagiellonian University in Krakow, Gronostajowa 2, 30-387 Kraków, Department of Inorganic Chemistry, Faculty of Chemistry, Jagiellonian University in Krakow, Gronostajowa 2, 30-387 Kraków



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