Shabir Ahmad Mir*
Listeria monocytogenes, a facultative intracellular gram-positive pathogen, is the causative agent of the disease listeriosis. The virulence of this intracellular bacterium is dependent on the coordinated activity of various bacterial factors, which are in turn tightly controlled by a specific set of regulators. The arsenal of virulence factors employed by L. monocytogenes for its infection cycle is available in the literature. Although the internalins of L. monocytogenes have been studied in detail their structural details are currently scattered and fragmented. Therefore, in the current review, we provide a brief account of the existing knowledge on structural details of the key internalins of L. monocytogenes and also highlight the recent advances in their functional aspects.
Listeriosis, Pathogenesis, Virulence, Virulence factors, Internalins, Listeria monocytogenes
Department of Medical Laboratory Sciences, College of Applied Medical Science, Majmaah Univer-sity, Al Majmaah-11952