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Synaptotagmin-1: A Multi-Functional Protein that Mediates Vesicle Docking, Priming, and Fusion

[ Vol. 22 , Issue. 6 ]

Author(s):

Najeeb Ullah*, Ezzouhra El Maaiden, Md. Sahab Uddin* and Ghulam Md. Ashraf   Pages 470 - 478 ( 9 )

Abstract:


The fusion of secretory vesicles with the plasma membrane depends on the assembly of v-SNAREs (VAMP2/synaptobrevin2) and t-SNAREs (SNAP25/syntaxin1) into the SNARE complex. Vesicles go through several upstream steps, referred to as docking and priming, to gain fusion competence. The vesicular protein synaptotagmin-1 (Syt-1) is the principal Ca2+ sensor for fusion in several central nervous system neurons and neuroendocrine cells and part of the docking complex for secretory granules. Syt-1 binds to the acceptor complex such as synaxin1, SNAP-25 on the plasma membrane to facilitate secretory vesicle docking, and upon Ca2+-influx, it promotes vesicle fusion. This review assesses the role of the Syt-1 protein involved in the secretory vesicle docking, priming, and fusion.

Keywords:

Synaptotagmin-1, vesicle docking, priming, fusion, exocytosis, secretory vesicles.

Affiliation:

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, Department of Pharmacy, Southeast University, Dhaka, Pre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah

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