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Ultrasound-Triggered Immunotherapy for Cancer Treatment: An Update

[ Vol. 22 , Issue. 6 ]

Author(s):

Debasmita Mukhopadhyay, Amal Ahmed, Catherine Sano, Nahid Awad, Nour Al Sawaftah and Ghaleb A. Husseini*   Pages 493 - 504 ( 12 )

Abstract:


Over the past few decades, immunotherapy has emerged as a promising therapeutic approach to treat some types of cancer. Moreover, antibody-based cancer therapies can trigger apoptosis and cell growth inhibition to induce immune cell destruction of target cells through antibody-dependent cellular cytotoxicity (ADCC). Nevertheless, immunotherapeutic efficiency is often restricted due to deficient delivery or low accumulation of therapeutic molecules at the tumor site. The development of pegylated liposomes with monoclonal antibodies conjugated to their surfaces (immunoliposomes) and triggered with ultrasound can effectively improve drug accessibility by enhancing cell membrane permeability and drug release. This review summarizes existing traditional cancer treatments and their limitations, emphasizing the recent advancements in ultrasound-triggered immunotherapy.

Keywords:

Ultrasound, immunotherapy, liposome, microbubbles, cancer, cell growth.

Affiliation:

Chemical Engineering Department, American University of Sharjah, Sharjah, Chemical Engineering Department, American University of Sharjah, Sharjah, Chemical Engineering Department, University of Virginia, Charlottesville, VA, Chemical Engineering Department, American University of Sharjah, Sharjah, Chemical Engineering Department, American University of Sharjah, Sharjah, Chemical Engineering Department, American University of Sharjah, Sharjah

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