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Recent Advances in Therapeutic Peptides for Breast Cancer Treatment

Author(s):

Samad Beheshtirouy, Farhad Mirzaei, Shirin Eyvazi* and Vahideh Tarhriz*   Pages 1 - 15 ( 15 )

Abstract:


Breast cancer is a heterogeneous malignancy which is the second cause of mortality among women in the world. Increasing the resistance to anti-cancer drugs in breast cancer cells persuades researchers to search the novel therapies approaches for the treatment of the malignancy. Among the novel methods, therapeutic peptides which target and disrupt tumor cells have been of great interest. Therapeutic peptides are short amino acids monomer chains with high specificity to bind and modulate a protein interaction of interest. Several advantages of peptides such as specific binding on tumor cells surface, low molecular weight and low toxicity on normal cells make the peptides as an appealing therapeutic agents against solid tumors, particularly breast cancer. Also, National Institutes of Health (NIH) describes therapeutic peptides as suitable candidate for the treatment of drug-resistant breast cancer. In this review, we attempt to review the different therapeutic peptides against breast cancer cells which can be used in treatment and diagnosis of the malignancy. Meanwhile, we presented an overview of peptide vaccines which have been developed for the treatment of breast cancer.

Keywords:

Therapeutic Peptides, Drug-resistant Tumor Cells, Breast Cancer

Affiliation:

Department of Cardiothoracic Surgery, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Department of Neurosurgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz



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