Carlos H. I. Ramos* and Kehinde S. Ayinde Pages 192 - 200 ( 9 )
Drug reposition, or repurposing, has become a promising strategy in therapeutics due to its advantages in several aspects of drug therapy. General drug development is expensive and can take more than 10 years to go through the designing, development, and necessary approval steps. However, established drugs have already overcome these steps and thus a potential candidate may be already available decreasing the risks and costs involved. In case of viral diseases, virus invades the cells of host organism and provoke biochemical changes in it that lead to tissue damage, alternations in normal physiological functions and sometimes death. Inside the cell, the virus finds the machinery necessary for its multiplication, as for instance the protein quality control system, which involves chaperones and Hsps (heat shock proteins) that, in addition to physiological functions, help in the stabilization of viral proteins. Recently, many inhibitors of Hsp90 have been developed as therapeutic strategies against diseases such as the Hsp90 inhibitors used in anticancer therapy. Several shreds of evidence indicate that these inhibitors can also be used as therapeutic strategies against viruses. Therefore, since a drug treatment for COVID-19 is urgently needed, this review aims to discuss the potential use of Hsp90 inhibitors in the treatment of this globally threatening disease.
Drug reposition, drug repurposing, Hsp90, Viral proteins, protein stabilization, protein folding, coronavirus, covid-19.
Institute of Chemistry, University of Campinas UNICAMP, Campinas SP, 13083-970, Institute of Chemistry, University of Campinas UNICAMP, Campinas SP, 13083-970