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Applications of iTRAQ and TMT Labeling Techniques to the Study of Neurodegenerative Diseases

[ Vol. 21 , Issue. 12 ]

Author(s):

Kelu Li, Zichao Chen, Yonggang Zhang and Xinglong Yang*   Pages 1202 - 1217 ( 16 )

Abstract:


Neurodegenerative diseases are caused by progressive lesions or loss of specific nerve cells, which endanger human health. However, the mechanism by which neurodegeneration manifests remains unclear. Proteomics can shed light on this question as well as help establish diagnostic standards and discover new drug targets. The power of proteomics for understanding neurodegenerative diseases has increased substantially with the application of iTRAQ and TMT labeling techniques. This review focuses on progress in these labeling techniques and their applications in neurodegeneration research.

Keywords:

Neurodegenerative diseases, iTRAQ, TMT, proteomics, quantitative neuroproteomics, neuro-imaging.

Affiliation:

Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, Institute of sports science, Sichuan University, No. 24 South Section 1, Yihuan Road, Chengdu, Sichuan Province, 610065, Department of Periodical Press and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032

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