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Insights into Peptide Mediated Antibiofilm Treatment in Chronic Wound: A Bench to Bedside Approach

[ Vol. 22 , Issue. 1 ]

Author(s):

Megha P. Radhakrishnan, Karthika Suryaletha, Aparna Shankar, Akhila Velappan Savithri, Sanil George and Sabu Thomas*   Pages 50 - 59 ( 10 )

Abstract:


Chronic wound biofilm infections are a threat to the population with respect to morbidity and mortality. The presence of multidrug-resistant bacterial pathogens in chronic wound renders the action of antibiotics and antibiofilm agents difficult. Therefore an alternative therapy is essential for reducing bacterial biofilm burden. In this scenario, the peptide-based antibiofilm therapy for chronic wound biofilm management seeks more attention. A synthetic peptide with a broad range of antibiofilm activity against preformed and established biofilms, having the ability to kill multispecies bacteria within biofilms and possessing combinatorial activity with other antimicrobial agents, provides significant insights. In this review, we portray the possibilities and difficulties of peptide-mediated treatment in chronic wounds biofilm management and how it can be clinically translated into a product.

Keywords:

Bacterial biofilm, antibiofilm agent, anti-microbial peptides (AMPs), delayed wound healing, combinatorial therapy, chronic.

Affiliation:

Cholera and Biofilm Research Laboratory, Pathogen Biology Group, Rajiv Gandhi Centre for Biotechnology, Govt. of India, Trivandrum - 695 014, Kerala, Cholera and Biofilm Research Laboratory, Pathogen Biology Group, Rajiv Gandhi Centre for Biotechnology, Govt. of India, Trivandrum - 695 014, Kerala, Cholera and Biofilm Research Laboratory, Pathogen Biology Group, Rajiv Gandhi Centre for Biotechnology, Govt. of India, Trivandrum - 695 014, Kerala, Cholera and Biofilm Research Laboratory, Pathogen Biology Group, Rajiv Gandhi Centre for Biotechnology, Govt. of India, Trivandrum - 695 014, Kerala, Interdisciplinary Biology, Rajiv Gandhi Centre for Biotechnology, Trivandrum - 695 014, Kerala, Cholera and Biofilm Research Laboratory, Pathogen Biology Group, Rajiv Gandhi Centre for Biotechnology, Govt. of India, Trivandrum - 695 014, Kerala

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