Yuan-Qing Pan and Li Xing* Pages 1 - 12 ( 12 )
RNA helicase A (RHA) is a DExH-box helicase that plays regulatory roles in a variety of cellular processes including transcription, translation, RNA splicing, editing, transport, and processing, microRNA genesis and maintenance of genomic stability. It is involved in virus replication, oncogenesis, and innate immune response. RHA can unwind nucleic acid duplex by nucleoside triphosphate hydrolysis. The insight into molecular mechanism of helicase activity is fundamental to understanding the role of RHA in the cell. Herein, we reviewed the current advances on the helicase activity of RHA and its relevance to gene expression, particularly, to genesis of circular RNA.
RNA helicase A, ATPase, Helicase activity, Unwinding, circRNAs
Institute of Biomedical Sciences, Shanxi University, 92 Wucheng Road, Taiyuan 030006, Shanxi province, Institute of Biomedical Sciences, Shanxi University, 92 Wucheng Road, Taiyuan 030006, Shanxi province