Submit Manuscript  

Article Details


Traceable Peptidic Ligands that Target Ghrelin Receptors

[ Vol. 21 , Issue. 10 ]

Author(s):

Mengjie Liu, John Wade* and Mohammed Akhter Hossain*   Pages 955 - 964 ( 10 )

Abstract:


Ghrelin is a 28-amino acid octanoylated peptide hormone that is implicated in many physiological and pathophysiological processes. Specific visualization of ghrelin and its cognate receptor using traceable ligands is crucial in elucidating the localization, functions, and expression pattern of the peptide’s signaling pathway. Here 12 representative radio- and fluorescently-labeled peptide-based ligands are reviewed for in vitro and in vivo imaging studies. In particular, the focus is on their structural features, pharmacological properties, and applications in further biochemical research.

Keywords:

ghrelin, ghrelin receptor, peptide, radiolabeling, fluorescence, ligand.

Affiliation:

Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010



Read Full-Text article