Submit Manuscript  

Article Details


The Advances of the Structure and Function of Indoleamine 2, 3- dioxygenase 1 and Its Inhibitors

[ Vol. 21 , Issue. 10 ]

Author(s):

Huai-Chuan Duan, Lian-Xin Peng , Yi-Chen Hu, Qing Luo, Xin-Yu Liu, Xin Sun, Li Liang, Ya Gan, Wei Liu, Hua Wan, Hu-Bing Shi*, Gang Zhao* and Jian-Ping Hu*   Pages 1027 - 1039 ( 13 )

Abstract:


Indoleamine 2, 3-dioxygenase 1 (IDO1) is the only rate-limiting enzyme outside the liver that catalyzes the oxidation and cracking of indole rings in the tryptophan along the kynurenine pathway (KP). The overactivation of IDO1 is closely related to the pathogenesis of various human immune and neurological diseases. As an important target for the treatment of many human serious diseases, including malignant tumors, the development of IDO1 inhibitors is of great practical significance. In this work, the structure and function of IDO1 both are summarized from the aspects of the signal pathway, catalytic mechanism, structural biology, and so on. Moreover, the current development status of IDO1 inhibitors is also systematically reviewed, which provides assistance for anti-cancer drug design based on the structure of receptors.

Keywords:

Tumor, indoleamine 2, 3-dioxygenase 1, signal path, catalytic mechanism, structural biology, drug design.

Affiliation:

College of Pharmacy and Bioengineering, Sichuan Industrial Institute of Antibiotics, Key Laboratory of Coarse Cereal Processing Ministry of Agriculture and Rural Affairs, Chengdu University, Chengdu, College of Pharmacy and Bioengineering, Sichuan Industrial Institute of Antibiotics, Key Laboratory of Coarse Cereal Processing Ministry of Agriculture and Rural Affairs, Chengdu University, Chengdu, College of Pharmacy and Bioengineering, Sichuan Industrial Institute of Antibiotics, Key Laboratory of Coarse Cereal Processing Ministry of Agriculture and Rural Affairs, Chengdu University, Chengdu, College of Pharmacy and Bioengineering, Sichuan Industrial Institute of Antibiotics, Key Laboratory of Coarse Cereal Processing Ministry of Agriculture and Rural Affairs, Chengdu University, Chengdu, Laboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, College of Pharmacy and Bioengineering, Sichuan Industrial Institute of Antibiotics, Key Laboratory of Coarse Cereal Processing Ministry of Agriculture and Rural Affairs, Chengdu University, Chengdu, College of Pharmacy and Bioengineering, Sichuan Industrial Institute of Antibiotics, Key Laboratory of Coarse Cereal Processing Ministry of Agriculture and Rural Affairs, Chengdu University, Chengdu, College of Pharmacy and Bioengineering, Sichuan Industrial Institute of Antibiotics, Key Laboratory of Coarse Cereal Processing Ministry of Agriculture and Rural Affairs, Chengdu University, Chengdu, College of Pharmacy and Bioengineering, Sichuan Industrial Institute of Antibiotics, Key Laboratory of Coarse Cereal Processing Ministry of Agriculture and Rural Affairs, Chengdu University, Chengdu, College of Mathematics and Informatics, South China Agricultural University, Guangzhou, Laboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, College of Pharmacy and Bioengineering, Sichuan Industrial Institute of Antibiotics, Key Laboratory of Coarse Cereal Processing Ministry of Agriculture and Rural Affairs, Chengdu University, Chengdu, College of Pharmacy and Bioengineering, Sichuan Industrial Institute of Antibiotics, Key Laboratory of Coarse Cereal Processing Ministry of Agriculture and Rural Affairs, Chengdu University, Chengdu



Read Full-Text article