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Protein and Antibody Engineering: Suppressing Degranulation of the Mast Cells and Type I Hypersensitivity Reaction

Author(s):

Huda Fatima Rajani*, Solmaz Shahidi and Mohammad Mahmoudi Gomari   Pages 1 - 11 ( 11 )

Abstract:


With an increase in atopic cases and owing to a significant role of mast cells in type I hypersensitivity, a therapeutic need to inhibit degranulation of mast cells has risen . Mast cells are notorious for IgE-mediated allergic response. Advancements have allowed researchers to improve the clinical outcomes of already available therapies. Engineered peptides and antibodies can be easily manipulated to attain desired characteristics as per the biological environment. A number of these molecules are designed to target mast cells, in order to regulate the release of histamine and other mediators, thereby, controlling type I hypersensitivity response. The aim of this review paper is to highlight some of the significant molecules designed for the purpose.

Keywords:

type I hypersensitivity, mast cells, degranulation, peptide engineering, antibody engineering, Fc receptors.

Affiliation:

Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran



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