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The Brief Analysis of Peptide-combined Nanoparticle: Nanomedicine’s Unique Value.

Author(s):

Jiemin Wang, Junyong Wu, Yongjiang Li, Jing Wen, Jiaxin Cai, Tiantian Tang, Xiongbin Hu and Daxiong Xiang*  

Abstract:


Therapeutic peptides (TPs) are biological macromolecules which can act as neurotransmitters, hormones, ion channel ligands and growth factors. Undoubtedly, TPs are crucial in the modern medicine. But low bio-stability and some special adverse reactions reduce their places to the application.

With the development of nanotechnology, nanoparticles (NPs) in pharmaceutical science gained much attention. They can encapsulate the TPs into their membrane or shell. Therefore, they can protect the TPs against degradation and then increase the bioavailability, which was thought to be the biggest advantage of them. Additionally, targeting was also studied to improve the effect of TPs. However, there were some drawbacks of nano TPs like low loading efficiency and difficulty to manufacture.

Nowadays, lots of studies focused on improving TPs’ effect by preparing nanoparticles. In this review, we presented the brief analysis of peptide-combined nanoparticles. Their advantages and disadvantages were listed in terms of mechanism. And several examples of applications were summarized.

Keywords:

Therapeutic peptides, Nanoparticle, Ligands, Active targeting, Passive targeting, Encapsulation, Drug delivery

Affiliation:

Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha



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