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Cellular Retinoic-Acid Binding Protein 2 in solid tumor

Author(s):

Xiaoyang Jiao*, Rang Liu, Jiali Huang, Lichun Lu, Zibo Li, Liyan Xu and Enmin Li  

Abstract:


The retinoic acid (RA) signaling pathway is crucial for many biological processes. The RA transporter, Cellular Retinoic-Acid Binding Protein 2 (CRABP2), abnormally expressed in various tumor types. CRABP2 presents significant effects on tumorous behaviors and functions, including cell proliferation, apoptosis, invasion, migration, metastasis, and angiogenesis. The tumorigenesis mechanism of CRABP2 as both suppressor and promotor is complicated, which remains ample space for further investigation. Elucidating the regulating mechanisms in a specific stage of the tumor could facilitate CRABP2 to be one biomarker in cancer diagnosis and prognosis. Besides, clarifying the pathways of CRABP2 in cancer development will contribute to the gene-targeted therapy. In this review, we summarized the expression, distribution, and mechanism of CRABP2 in solid tumors. Illuminating the CRABP2 signaling pathway may benefit understanding the retinoid signaling pathway, providing a useful biomarker for future clinical trials.

Keywords:

CRABP2, Retinoic-acid, signaling pathway, tumor

Affiliation:

Cell biology and genetics department, Shantou University Medical College Shantou, Guangdong, The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College Shantou, Guangdong, The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College Shantou, Guangdong, The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College Shantou, Guangdong, The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College Shantou, Guangdong, The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College Shantou, Guangdong, Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, Guangdong



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