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Progress in the development of antimicrobial peptide prediction tools

Author(s):

Chunyan Ao , Yu Zhang , Dapeng Li , Yuming Zhao * and Quan Zou *  

Abstract:


Antimicrobial peptides (AMPs) are natural polypeptides with antimicrobial activities and are found in most organisms. AMPs are evolutionarily conservative components that belong to the innate immune system and show potent activity against bacteria, fungi, viruses and in some cases display antitumor activity. Thus, AMPs are major candidates in the development of new antibacterial reagents. In the last few decades, AMPs have attracted significant attention from the research community. During the early stages of the development of this research field, AMPs were experimentally identified, which is an expensive and time-consuming procedure. Therefore, research and development (R&D) of fast, highly efficient computational tools for predicting AMPs has enabled the rapid identification and analysis of new AMPs from a wide range of organisms. Moreover, these computational tools have allowed researchers to better understand the activities of AMPs, which has promoted R&D of antibacterial drugs. In this review, we systematically summarize AMP prediction tools and their corresponding algorithms used.

Keywords:

Antimicrobial Peptides; Machine Learning; Support Vector Machine; Random Forest; Artificial Neural Network

Affiliation:

Institute of Fundamental and Frontier Sciences - University of Electronic Science and Technology of China Chengdu, Department of neurosurgery - Heilongjiang Province Land Reclamation Headquarters General Hospital Harbin, Department of Internal Medicine-Oncology - The Fourth Hospital in Qinhuangdao Hebei, Information and Computer Engineering College - Northeast Forestry University Harbin, Institute of Fundamental and Frontier Sciences - University of Electronic Science and Technology of China Chengdu



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