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Role of BCL-2 Family Proteins in Apoptosis and its Regulation by Nutrients

Author(s):

Chen Zheng, Ting Liu, Huihui Liu and Jing Wang*   Pages 1 - 8 ( 8 )

Abstract:


In the body, millions of cells die and proliferate each day to maintain normal function and cooperation of all tissues, organs, and systems. Thus, programmed cell death, or apoptosis, is critical to sustain growth, development, and body health. The vital role of B-cell leukemia/lymphoma-2 (BCL-2) family proteins in apoptosis has been identified. The BCL-2 family includes both pro- and anti-apoptotic proteins, which are structurally and functionally related, containing up to four BCL-2 homology (BH) motifs (BH1-4). There are also nutritional factors that regulate apoptosis via the BCL-2 family proteins. In this review, the BCL-2 family proteins and their apoptosis-inducing mechanism have been discussed, along with the nutrient factors that regulating apoptosis through the BCL-2 family proteins.

Keywords:

BCL-2 family proteins, apoptosis, regulation, nutrients

Affiliation:

College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing



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