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Application of Genetic Engineering Approaches to Improve Bacterial Metabolite Production

[ Vol. 21 , Issue. 5 ]

Author(s):

Xin Xie, Jia-Wei Zhu, Yi Liu and Hui Jiang*   Pages 488 - 496 ( 9 )

Abstract:


Genetic engineering is a powerful method to improve the fermentation yield of bacterial metabolites. Since many biosynthetic mechanisms of bacterial metabolites have been unveiled, genetic engineering approaches have been applied to various issues of biosynthetic pathways, such as transcription, translation, post-translational modification, enzymes, transporters, etc. In this article, natamycin, avermectins, gentamicins, piperidamycins, and β-valienamine have been chosen as examples to review recent progress in improving their production by genetic engineering approaches. In these cases, not only yields of target products have been increased, but also yields of by-products have been decreased, and new products have been created.

Keywords:

Metabolite, genetic engineering, biosynthesis, enzyme, fermentation, metabolites.

Affiliation:

College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058

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