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Consequences of Dicarbonyl Stress on Skeletal Muscle Proteins in Type 2 Diabetes

Author(s):

Khurshid Ahmad, Sibhghatulla Shaikh, Eun Ju Lee, Yong-Ho Lee and Inho Choi*   Pages 1 - 12 ( 12 )

Abstract:


Skeletal muscle is the largest organ in the body and constitutes almost 40% of body mass. It is also the primary site of insulin-mediated glucose uptake, and skeletal muscle insulin resistance, that is, diminished response to insulin, is characteristic of Type 2 diabetes (T2DM). One of the foremost reasons posited to explain the etiology of T2DM involves the modification of proteins by dicarbonyl stress due to an unbalanced metabolism and accumulations of dicarbonyl metabolites. The elevated concentration of dicarbonyl metabolites (i.e., glyoxal, methylglyoxal, 3-deoxyglucosone) leads to DNA and protein modifications, causing cell/tissue dysfunctions in several metabolic diseases such as T2DM and other age-associated diseases. In this review, we recapitulate reported effects of dicarbonyl stress on skeletal muscle and associated extracellular proteins with emphasis on the impact of T2DM on skeletal muscle and provide a brief introduction to the prevention/inhibition of dicarbonyl stress.

Keywords:

Skeletal muscle, Insulin resistance, Diabetes, Reactive dicarbonyl and glycolytic intermediates, Dicarbonyl stress

Affiliation:

Department of Medical Biotechnology, Yeungnam University, Gyeongsan, Department of Medical Biotechnology, Yeungnam University, Gyeongsan, Department of Medical Biotechnology, Yeungnam University, Gyeongsan, Department of Biomedical Sciences, Daegu Catholic University, Gyeongsan, 38430, Department of Medical Biotechnology, Yeungnam University, Gyeongsan



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