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The Functional Significance of Endocrine-immune Interactions in Health and Disease

[ Vol. 21 , Issue. 1 ]

Author(s):

Sridhar Muthusami*, Balasubramanian Vidya*, Esaki M Shankar, Jamuna Vadivelu, Ilangovan Ramachandran, Jone A Stanley and Nagarajan Selvamurugan   Pages 52 - 65 ( 14 )

Abstract:


Hormones are known to influence various body systems that include skeletal, cardiac, digestive, excretory, and immune systems. Emerging investigations suggest the key role played by secretions of endocrine glands in immune cell differentiation, proliferation, activation, and memory attributes of the immune system. The link between steroid hormones such as glucocorticoids and inflammation is widely known. However, the role of peptide hormones and amino acid derivatives such as growth and thyroid hormones, prolactin, dopamine, and thymopoietin in regulating the functioning of the immune system remains unclear. Here, we reviewed the findings pertinent to the functional role of hormone-immune interactions in health and disease and proposed perspective directions for translational research in the field.

Keywords:

Immune system, endocrine system, protein, peptide, cross talk.

Affiliation:

Department of Biochemistry, Karpagam Academy of Higher Education, Eachanari, Coimbatore 641021, Tamil Nadu, Department of Biochemistry, Karpagam Academy of Higher Education, Eachanari, Coimbatore 641021, Tamil Nadu, Department of Life Sciences, School of Life Sciences, Central University of Tamil Nadu, Thiruvarur 610005, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Lembah Pantai, Kuala Lumpur 50603, Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, Tamil Nadu4Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, Tamil Nadu, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas 77843, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu



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