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Cockroaches: Allergens, Component-Resolved Diagnosis (CRD) and Component- Resolved Immunotherapy

[ Vol. 21 , Issue. 2 ]

Author(s):

Nitat Sookrung, Anchalee Tungtrongchitr* and Wanpen Chaicumpa   Pages 124 - 141 ( 18 )

Abstract:


Allergic diseases are assuming increasing trend of prevalence worldwide. The diseases confer increasing demand on medical and healthcare facilities. Patients with allergies have poor quality of life and impaired cognition. Adult patients have subpar working efficiency while afflicted children are less effective at school, often have school absenteeism and need more attention of their caregivers. All of them lead to negative socio-economic impact. This narrative review focuses on cockroach allergy including currently recognized cockroach allergens, pathogenic mechanisms of allergy, componentresolved diagnosis and allergen-specific immunotherapy, particularly the component-resolved immunotherapy and the molecular mechanisms that bring about resolution of the chronic airway inflammation.

Keywords:

Allergens, cockroach, component-resolved diagnosis (CRD), component-resolved immunotherapy, (CRIT), Th2 response, tissue remodeling.

Affiliation:

Biomedical Research Incubator Unit, Department of Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok



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