Submit Manuscript  

Article Details


Biochemical Characteristics and Allergenic Activity of Common Fungus Allergens

[ Vol. 21 , Issue. 2 ]

Author(s):

Lisha Li, Kai Guan* and Song Guo Zheng*   Pages 170 - 185 ( 16 )

Abstract:


Fungi form a large kingdom with more than 1.5 million species. Fungal spores are universal atmospheric components and are generally recognized as important causes of allergic disorders, including allergic rhinitis, allergic rhinosinusitis, asthma, and allergic bronchopulmonary aspergillosis. The 4 genera which have the closest connection with allergic disorder are Cladosporium, Alternaria, Aspergillus and Penicillium. The cDNA sequences of many fungi allergens and the amino acids involved in their immunoglobulin E binding and T-cell activation have already been elucidated. Until now, 111 allergens from 29 fungal genera have been approved by the International Allergen Nomenclature Sub-committee. This review mainly focuses on the biochemical characteristics and allergenic activity of important allergens from common environmental fungi.

Keywords:

Fungus, allergen, respiratory allergy, Alternaria, Cladosporium, Penicillium, Aspergillus.

Affiliation:

Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, Beijing, 100730, Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, Beijing, 100730, Ohio State College of Medicine, Ohio State University, Columbus, OH 43210

Graphical Abstract:



Read Full-Text article