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Ligand Potency, Efficiency and Drug-likeness: A Story of Intuition, Misinterpretation and Serendipity

[ Vol. 20 , Issue. 11 ]

Author(s):

Jaroslaw Polanski*, Anna Pedrys, Roksana Duszkiewicz and Urszula Kucia   Pages 1069 - 1076 ( 8 )

Abstract:


The concept of ligand potency is briefly discussed here as well as why this is still a challenge for its complete comprehension. In this context, we explain also the meaning of ligand efficiency (LE), which has been greeted with both enthusiasm and criticism among the drug design audience. A full understanding of LE requires the complex interpretation of the potency concept presenting the uncertainty similar to this of the Zeno paradox. In reality, the efficiency of LE is caused by the high degree of preference for slim pharma drug candidates.

Keywords:

Ligand efficiency, potency, biological activity, Big Data, drug design, PubChem, ChEMBL.

Affiliation:

Institute of Chemistry, University of Silesia, Szkolna 9, 40-006 Katowice, Institute of Chemistry, University of Silesia, Szkolna 9, 40-006 Katowice, Institute of Chemistry, University of Silesia, Szkolna 9, 40-006 Katowice, Institute of Chemistry, University of Silesia, Szkolna 9, 40-006 Katowice

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