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Strategies for Oral Delivery of Metal-Saturated Lactoferrin

[ Vol. 20 , Issue. 11 ]

Author(s):

Przemysław Gajda-Morszewski, Klaudyna Śpiewak-Wojtyła, Maria Oszajca and Małgorzata Brindell*   Pages 1046 - 1051 ( 6 )

Abstract:


Lactoferrin was isolated and purified for the first time over 50-years ago. Since then, extensive studies on the structure and function of this protein have been performed and the research is still being continued. In this mini-review we focus on presenting recent scientific efforts towards the elucidation of the role and therapeutic potential of lactoferrin saturated with iron(III) or manganese(III) ions. The difference in biological activity of metal-saturated lactoferrin vs. the unmetalated one is emphasized. The strategies for oral delivery of lactoferrin, are also reviewed, with particular attention to the metalated protein.

Keywords:

Lactoferrin, iron saturated-lactoferrin, manganese-saturated lactoferrin, oral delivery, biological activity, metalated protein.

Affiliation:

Department of Inorganic Chemistry, Faculty of Chemistry, Jagiellonian University in Krakow, Gronostajowa 2, 30-387 Krakow, Department of Inorganic Chemistry, Faculty of Chemistry, Jagiellonian University in Krakow, Gronostajowa 2, 30-387 Krakow, Department of Inorganic Chemistry, Faculty of Chemistry, Jagiellonian University in Krakow, Gronostajowa 2, 30-387 Krakow, Department of Inorganic Chemistry, Faculty of Chemistry, Jagiellonian University in Krakow, Gronostajowa 2, 30-387 Krakow

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