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Natural Products: Potential Source of DPP-IV Inhibitors

[ Vol. 20 , Issue. 12 ]

Author(s):

Rajeev K. Singla*, Rishabh Kumar, Sameer Khan, Mohit, Kajal Kumari and Arun Garg   Pages 1218 - 1225 ( 8 )

Abstract:


Out of multiple therapeutic targets, DPP-IV is the lead target for the treatment of type 2 diabetes. Natural products have always been available for the possible lead generation against various diseases and disorders. In the present review, we have covered various natural sources which have experimentally validated anti-diabetic activity for type 2 diabetic patients with specific focus on the DPP-IV inhibition. Out of all, the most potent DPP-IV inhibitors were found to be resveratrol, luteolin, apigenin and flavone having activity in nanomolar range. Standard drugs like sitagliptin, saxagliptin, and diprotin A have complex structures as compared to these phenolic compounds. Flavonoids and phenolic compounds have their added advantages in being present in a number of functional foods and carry antioxidant properties as well. So, the scientists working on the new chemical entity hunting for the type 2 diabetes treatment can also explore these natural sources for lead generation.

Keywords:

Dipeptidyl-peptidase IV, antidiabetes, type 2 diabetes, natural medicines, phenolic compounds, sitagliptin.

Affiliation:

Drug Design & Discovery Laboratory, School of Medical and Allied Sciences, K.R. Mangalam University, Sohna Road, Gurugram, Drug Design & Discovery Laboratory, School of Medical and Allied Sciences, K.R. Mangalam University, Sohna Road, Gurugram, Drug Design & Discovery Laboratory, School of Medical and Allied Sciences, K.R. Mangalam University, Sohna Road, Gurugram, Drug Design & Discovery Laboratory, School of Medical and Allied Sciences, K.R. Mangalam University, Sohna Road, Gurugram, Drug Design & Discovery Laboratory, School of Medical and Allied Sciences, K.R. Mangalam University, Sohna Road, Gurugram, Drug Design & Discovery Laboratory, School of Medical and Allied Sciences, K.R. Mangalam University, Sohna Road, Gurugram



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