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Mitochondrial Dysfunction in Skeletal Muscle Pathologies

[ Vol. 20 , Issue. 6 ]

Author(s):

Johanna Abrigo, Felipe Simon, Daniel Cabrera, Cristian Vilos and Claudio Cabello-Verrugio*   Pages 536 - 546 ( 11 )

Abstract:


Several molecular mechanisms are involved in the regulation of skeletal muscle function. Among them, mitochondrial activity can be identified. The mitochondria is an important and essential organelle in the skeletal muscle that is involved in metabolic regulation and ATP production, which are two key elements of muscle contractibility and plasticity. Thus, in this review, we present the critical and recent antecedents regarding the mechanisms through which mitochondrial dysfunction can be involved in the generation and development of skeletal muscle pathologies, its contribution to detrimental functioning in skeletal muscle and its crosstalk with other typical signaling pathways related to muscle diseases. In addition, an update on the development of new strategies with therapeutic potential to inhibit the deleterious impact of mitochondrial dysfunction in skeletal muscle is discussed.

Keywords:

Mitochondria, ROS, skeletal muscle, atrophy, dystrophy, ATP production.

Affiliation:

Millennium Institute on Immunology and Immunotherapy, Santiago, Millennium Institute on Immunology and Immunotherapy, Santiago, Departamento de Gastroenterologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Center for the Development of Nanoscience and Nanotechnology (CEDENNA), Universidad de Santiago de Chile, Santiago, Millennium Institute on Immunology and Immunotherapy, Santiago

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