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In Silico and Molecular Docking Studies that Address Viral (STD) Transmission Points

Author(s):

Alex France Messias Monteiro, Jessika de Oliveira Viana, Engene Muratov, Marcus Tullius Scotti and Luciana Scotti*   Pages 1 - 16 ( 16 )

Abstract:


Sexually transmitted diseases (STDs) refer to a variety of clinical syndromes and infections caused by pathogens that can be acquired and transmitted through sexual activity. Among STDs widely reported in the literature, viral sexual diseases have been increasing in number of cases globally. This emphasizes the need for prevention and treatment. Among the methods widely used in drug planning are computer-aided drug design (CADD) studies and molecular docking which has the objective of investigating molecular interactions between two molecules to better understand the three -dimensional structural characteristics of the compounds. This review will discuss molecular docking studies applied to viral STDs such as Ebola virus, Herpes virus and HIV, and reveal promising new drug candidates with high levels of specificity to their respective targets.

Keywords:

Sexually transmitted diseases, antiviral drugs, in silico, molecular docking, HIV, infection

Affiliation:

Program of Natural and Synthetic Bioactive Products (PgPNSB), Health Sciences Center, Federal University of Paraíba, João Pessoa-PB, Program of Natural and Synthetic Bioactive Products (PgPNSB), Health Sciences Center, Federal University of Paraíba, João Pessoa-PB, Teaching and Research Management - University Hospital, Federal University of Paraíba, Campus I, 58051-900, João Pessoa-PB, Program of Natural and Synthetic Bioactive Products (PgPNSB), Health Sciences Center, Federal University of Paraíba, João Pessoa-PB, Program of Natural and Synthetic Bioactive Products (PgPNSB), Health Sciences Center, Federal University of Paraíba, João Pessoa-PB



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