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Crosstalk between the CX3CL1/CX3CR1 Axis and Inflammatory Signaling Pathways in Tissue Injury

[ Vol. 20 , Issue. 8 ]

Author(s):

Quan Zhuang, Jiarui Ou, Sheng Zhang and Yingzi Ming*   Pages 844 - 854 ( 11 )

Abstract:


During inflammation, chemokines play a central role by mediating the activation of inflammatory cascade responses in tissue injury. Among more than 200 chemokines, CX3CL1 is a special chemotactic factor existing in both membrane-bound and soluble forms. Its only receptor, CX3CR1, is a member of the G protein-coupled receptor superfamily. The CX3CL1/CX3CR1 axis can affect many inflammatory processes by communicating with different inflammatory signaling pathways, such as JAK-STAT, Toll-like receptor, MAPK, AKT, NF-κB, Wnt/β-catenin, as well as others. These inflammatory networks are involved in much pathology. Determining the crosstalk between the CX3CL1/CX3CR1 axis and these inflammatory signaling pathways could contribute to solving problems in tissue injury, and the CX3CL1/CX3CR1 axis may be a better therapeutic target than inflammatory signaling pathways for preventing tissue injury due to the complexity of inflammatory signaling networks.

Keywords:

CX3CL1, CX3CR1, inflammatory signaling pathway, tissue injury, chemokines, pathology.

Affiliation:

Transplantation Center of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, Transplantation Center of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, Transplantation Center of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013

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