Submit Manuscript  

Article Details


Role of Autophagy in Chronic Liver Inflammation and Fibrosis

[ Vol. 20 , Issue. 8 ]

Author(s):

Yu-Jen Tseng, Ling Dong, Yu-Feng Liu, Nuo Xu, Wei Ma, Shu-Qiang Weng, Harry L.A. Janssen* and Sheng-Di Wu*   Pages 817 - 822 ( 6 )

Abstract:


Autophagy entails the removal of dysfunctional components to maintain cellular homeostasis. Over the years, studies of autophagy demonstrated its complex physiological and pathological roles in the liver. Apart from regulation of normal metabolic functions such as glycogenolysis, glycogenesis, and β-oxidation, autophagy also contributes to the modulation of various liver diseases. In this review, we provide a concise overview of the role of autophagy in regulating hepatic metabolism in healthy conditions and various chronic liver diseases. A well-rounded understanding of the role of autophagy may provide insight for future medical advancements in the field of hepatology.

Keywords:

Autophagy, chronic liver inflammation, lipophagy, macroautophagy, microautophagy, fibrosis.

Affiliation:

Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, Department of Nursing, General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, Francis Family Liver Clinic, University of Toronto & University Health Network, Toronto, ON, Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032

Graphical Abstract:



Read Full-Text article