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The Immune System Regulation in Sepsis: From Innate to Adaptive

[ Vol. 20 , Issue. 8 ]

Author(s):

Yue Qiu, Guo-wei Tu, Min-jie Ju, Cheng Yang* and Zhe Luo*   Pages 799 - 816 ( 18 )

Abstract:


Sepsis, which is a highly heterogeneous syndrome, can result in death as a consequence of a systemic inflammatory response syndrome. The activation and regulation of the immune system play a key role in the initiation, development and prognosis of sepsis. Due to the different periods of sepsis when the objects investigated were incorporated, clinical trials often exhibit negative or even contrary results. Thus, in this review we aim to sort out the current knowledge in how immune cells play a role during sepsis.

Keywords:

Sepsis, innate immunity, adaptive immunity, inflammation, protein, immune system.

Affiliation:

Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, Department of Urology, Zhongshan Hospital; Shanghai Key Laboratory of Organ Transplantation, Fudan University, Shanghai 200032, Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032

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