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Isoleucine Plays an Important Role for Maintaining Immune Function

Author(s):

Changsong Gu*, Xiangbing Mao*, Daiwen Chen, Bing Yu and Qing Yang   Pages 1 - 8 ( 8 )

Abstract:


Branched chain amino acids are the essential nutrients for humans and many animals. As functional amino acids,they play important roles in physiological functions, including immune functions. Isoleucine, as one of the branched chainamino acids, is also critical in physiological functions of the whole body, such as growth, immunity, protein metabolism, fattyacid metabolism and glucose transportation. Isoleucine can improve the immune system, including immune organs, cells andreactive substances. Recent studies have also shown that isoleucine may induce the expression of host defense peptides (i.e.,β-defensins) that can regulate host innate and adaptive immunity. In addition, isoleucine administration can restore the effectof some pathogens on the health of humans and animals via increasing the expression of β-defensins. Therefore, the present review will emphatically discuss the effect of isoleucine on immunity while summarizing the relationship between branchedchain amino acids and immune functions.

Keywords:

Isoleucine, branched chain amino acids, immune system, β-defensins, TLR/NF-κB pathway, ERK pathway.

Affiliation:

Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, Department of Animal Science, Oklahoma State University, Stillwater, Oklahoma, KS



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