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The Role of Neuropeptide Y and Peptide YY in the Development of Obesity via Gut-brain Axis

Author(s):

Yi Wu, Hengxun He, Zhibin Cheng, Yueyu Bai and Xi Ma*   Pages 1 - 9 ( 9 )

Abstract:


Obesity is one of the main challenges of public health in the 21st century. Obesity can induce a series of chronic metabolic diseases, such as diabetes, dyslipidemia, hypertension and nonalcoholic fatty liver, which seriously affect human health. Gut-brain axis, the two-direction pathway formed between the enteric nervous system and the central nervous system, plays a vital role in the occurrence and development of obesity. Gastrointestinal signals are projected through the gut-brain axis to nervous system, and respond to various gastrointestinal stimulation. The central nervous system regulates visceral activity through the gut-brain axis. Brain-gut peptides have important regulatory roles in the gut-brain axis. The brain-gut peptides of gastrointestinal system and the nervous system regulate the gastrointestinal movement, feeling, secretion, absorption and other complex functions through endocrine, neurosecretion and paracrine to secrete peptides. Both neuropeptide Y and peptide YY belong to the pancreatic polypeptide family and are important brain-gut peptides. Neuropeptide Y and peptide YY have functions that are closely related to appetite regulation and obesity formation. This review describes the role of the gut-brain axis in regulating appetite and maintaining energy balance, and the functions of brain-gut peptides neuropeptide Y and peptide YY in obesity. The relationship between NPY and PYY and the interaction between the NPY-PYY signaling with the gut microbiota are also described in this review.

Keywords:

gut-brain axis, obesity, neuropeptide Y, peptide YY, brain-gut peptide, gut microbiota.

Affiliation:

China Agricultural University - State Key Lab of Animal Nutrition, College of Animal Science and Technology Beijing, China Agricultural University - State Key Lab of Animal Nutrition, College of Animal Science and Technology Beijing, Yunnan Agriculture University - College of animal science and technology Kunming, China Agricultural University - State Key Lab of Animal Nutrition, College of Animal Science and Technology Beijing, China Agricultural University (CAU) - Ministry of Agriculture Feed Industry Centre (MAFIC) College of Animal Science and Technology State Key Laboratory of Animal Nutrition



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