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The Underlying Regulated Mechanisms of Adipose Differentiation and Apoptosis of Breast Cells after Weaning

Author(s):

Yanbin Dong, Weihang Gao, Zhao Gao, Shuqi Pu, Xiaowen Xu, Xingping Yang, Yuan Zhang, Kui Fang, Jie Li, Weijian Yu, Nannan Sun, Ling Hu*, Qin Xu, Zhibin Cheng and Yong Gao*   Pages 1 - 9 ( 9 )

Abstract:


Numerous experimental studies have demonstrated that a series of remodeling processes occurred in the adipose tissue during the weaning, such as differentiation. Fibroblasts in the breast at weaning stage could re-differentiate into mature adipocytes. Many transcriptional factors were involved in these processes, especially the PPARγ, C/EBP, and SREBP1. There is cell apoptosis participating in the breast tissue degeneration and secretory epithelial cells loss during weaning. In addition, hormones, especially the estrogen and pituitary hormone, play a vital role in the whole reproductive processes. In this review, we mainly focus on the underlying regulated mechanisms of differentiation of adipose tissue and apoptosis of breast cell to provide a specific insight into the physiological changes during weaning

Keywords:

Adipose tissue, After weaning, Mammary gland, Adipose differentiation, C/EBP, ADD1/SREB.

Affiliation:

College of PIWEI institute, Guangzhou University of Chinese Medicine, Guangzhou, 510405, College of PIWEI institute, Guangzhou University of Chinese Medicine, Guangzhou, 510405, Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, College of PIWEI institute, Guangzhou University of Chinese Medicine, Guangzhou, 510405, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510405, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, 510080, Administration of Sports of Guangdong Province, Guangzhou, Guangdong, 510105, Administration of Sports of Guangdong Province, Guangzhou, Guangdong, 510105, Administration of Sports of Guangdong Province, Guangzhou, Guangdong, 510105, Administration of Sports of Guangdong Province, Guangzhou, Guangdong, 510105, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510405, College of PIWEI institute, Guangzhou University of Chinese Medicine, Guangzhou, 510405, Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, College of Animal Science and Technology, Yunnan Agricultural University, Kunming, Yunan, 650201, College of PIWEI institute, Guangzhou University of Chinese Medicine, Guangzhou, 510405



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