Submit Manuscript  

Article Details


Adipocytes-released Peptides Involved in the Control of Gastrointestinal Motility

[ Vol. 20 , Issue. 6 ]

Author(s):

Eglantina Idrizaj, Rachele Garella, Roberta Squecco and Maria Caterina Baccari*   Pages 614 - 629 ( 16 )

Abstract:


The present review focuses on adipocytes-released peptides known to be involved in the control of gastrointestinal motility, acting both centrally and peripherally. Thus, four peptides have been taken into account: leptin, adiponectin, nesfatin-1, and apelin. The discussion of the related physiological or pathophysiological roles, based on the most recent findings, is intended to underlie the close interactions among adipose tissue, central nervous system, and gastrointestinal tract. The better understanding of this complex network, as gastrointestinal motor responses represent peripheral signals involved in the regulation of food intake through the gut-brain axis, may also furnish a cue for the development of either novel therapeutic approaches in the treatment of obesity and eating disorders or potential diagnostic tools.

Keywords:

Adiponectin, apelin, gastrointestinal motility, leptin, nesfatin-1, smooth muscle.

Affiliation:

Department of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence, Department of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence, Department of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence, Department of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence

Graphical Abstract:



Read Full-Text article