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ConBr, The Lectin From Canavalia brasiliensis Mart. Seeds: Forty Years Of Research

Author(s):

Benildo Sousa Cavada*, Vinicius Jose Silva Osterne, Vanir Reis Pinto-Junior and Kyria Santiago Nascimento  

Abstract:


Lectins are defined as proteins or glycoproteins capable of specific and reversible binding to carbohydrates. Inside this group of proteins, the most well studied lectins belong to the family Leguminosae, and inside this family, the Diocleinae subtribe presents the extensively characterized lectin Concanavalin A (ConA), as well as ConBr, the lectin from Canavalia brasiliensis, the subject of this review. Since 1979, several studies have been published in the literature regarding this lectin, from its isolation and characterization to its several biological activities. This year, 2019, will mark 40 years since researchers have begun to study ConBr and 100 years since the discovery of ConA, making 2019 a momentous year for lectinology. Owing to the abundance of studies involving ConBr, this review will focus on ConBr’s purification, physicochemical properties, functional and structural analyses, biological activities and biotechnological applications. This will give researchers a broad glimpse into the potential of this lectin, as well as it characteristics, as we look ahead to its expanding applications in glycomics and biotechnology.

Keywords:

Canavalia brasiliensis, Lectin, ConBr, Biological Activities, Properties, Lectinology.

Affiliation:

BioMol-Lab, Department of Biochemistry and Molecular Biology, Federal University of Ceará, BioMol-Lab, Department of Biochemistry and Molecular Biology, Federal University of Ceará, BioMol-Lab, Department of Biochemistry and Molecular Biology, Federal University of Ceará, BioMol-Lab, Department of Biochemistry and Molecular Biology, Federal University of Ceará



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