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Emerging Antitumor Activities of the Bitter Melon (Momordica charantia)

[ Vol. 20 , Issue. 3 ]

Author(s):

Evandro Fei Fang*, Lynn Froetscher, Morten Scheibye-Knudsen, Vilhelm A. Bohr, Jack Ho Wong and Tzi Bun Ng*   Pages 296 - 301 ( 6 )

Abstract:


Bitter melon or bitter gourd (Momordica charantia) is a common vegetable in Asia and it is distinctive for its bitter taste. As an ingredient in folk medicine, research from different laboratories in recent years supports its potential medicinal applications with anti-tumor, anti-diabetic, anti-HIV activities in both in vitro and animal studies. In this short review, we summarize herein the recent progress in the antitumor aspect of bitter melon with a focus on the underlying molecular mechanisms. Further mechanistic studies as well as clinical trials are necessary to further verify its medicinal applications.

Keywords:

Momordica charantia, bitter melon, anticancer, apoptosis, DNA damage, medicinal applications.

Affiliation:

Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Laboratory of Molecular Gerontology, National Institute on Aging, NIH, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong



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