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Central Role of Transforming Growth Factor Type Beta 1 in Skeletal Muscle Dysfunctions: An Update on Therapeutic Strategies

[ Vol. 19 , Issue. 12 ]

Author(s):

Johanna Abrigo, Felipe Simon, Daniel Cabrera, Gonzalo Cordova, Capucine Trollet and Claudio Cabello-Verrugio*   Pages 1189 - 1200 ( 12 )

Abstract:


Among the soluble factors that regulate skeletal muscle function, Transforming Growth Factor type Beta 1 (TGF-β1) is one of the most studied. This factor inhibits myogenesis and regeneration by regulating the activity and function of satellite cells (SCs). Indeed, TGF-β has a central role in muscle pathologies in which there is development of fibrosis and/or atrophy of skeletal muscle. Thus, in this review we present the critical and recent antecedents regarding the mechanisms and cellular targets involved in the effects of TGF-β1 in the muscle, in pathological processes such as the inhibition of regeneration, fibrosis and atrophy. In addition, an update on the development of new strategies with therapeutic potential to inhibit the deleterious actions of TGF-β in skeletal muscle is discussed.

Keywords:

Muscle atrophy, fibrosis, dystrophy, renin angiotensin system, blocking antibodies, therapy.

Affiliation:

Millennium Institute on Immunology and Immunotherapy, Santiago, Millennium Institute on Immunology and Immunotherapy, Santiago, Departamento de Gastroenterologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Sorbonne Universites, UPMC Univ Paris 6, UM76, INSERM U974, Institut de Myologie, 47 bd de l`Hopital, 75013 Paris, Sorbonne Universites, UPMC Univ Paris 6, UM76, INSERM U974, Institut de Myologie, 47 bd de l`Hopital, 75013 Paris, Millennium Institute on Immunology and Immunotherapy, Santiago

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