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Chemotherapeutic Drugs and Plasma Proteins: Exploring New Dimensions

[ Vol. 19 , Issue. 10 ]

Author(s):

Mohammad Khalid Zia, Tooba Siddiqui, Syed Saqib Ali, Ahmed Abdur Rehman, Haseeb Ahsan and Fahim Halim Khan*   Pages 937 - 947 ( 11 )

Abstract:


In the last few decades, advances in the cancer chemotherapy have been a marked success. A large number of anticancer drugs currently in use include drugs based on platinum complexes such as cisplatin, base analogues such as 5-florouracil and some ruthenium drugs. This review provides a bird’s eye view of interaction of a number of clinically important drugs currently in use that show covalent or non-covalent interaction with serum proteins. Platinum drug-cisplatin interacts covalently and alters the function of the key plasma protease inhibitor molecule -alpha-2-macroglobulin and induces the conformational changes in the protein molecule and inactivates it. 5-fluorouracil (5-FU) is extensively metabolized and at physiological concentrations, is found to be associated with Human Serum Albumin (HSA). Similarly ruthenium compounds bind tightly to plasma proteins- serum albumin and serum transferrin, modifying their biological activity and increasing the toxicity of drug to cancer cells. Insight into varied anticancer drug- protein interaction will go a long way in understanding in totality of the mechanism of action of any anticancer drug and its possible effects/side effects.

Keywords:

Alpha-2-macroglobulin, cisplatin, 5-FU, chemotherapeutic drugs, plasma proteins, new dimensions.

Affiliation:

Department of Biochemistry, Faculty of Life Science, Aligarh Muslim University, Aligarh, Department of Biochemistry, Faculty of Life Science, Aligarh Muslim University, Aligarh, Department of Biochemistry, Faculty of Life Science, Aligarh Muslim University, Aligarh, Department of Biochemistry, Faculty of Life Science, Aligarh Muslim University, Aligarh, Department of Biochemistry, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, Department of Biochemistry, Faculty of Life Science, Aligarh Muslim University, Aligarh

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