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Effects of Apelin Peptides on Diabetic Complications

[ Vol. 19 , Issue. 2 ]

Author(s):

Hong Chen, Chengyu Liu, Cheng Cheng, Ling Zheng and Kun Huang*   Pages 179 - 189 ( 11 )

Abstract:


Diabetes is a metabolic disorder with multiple complications, including cardiomyopathy, retinopathy, nephropathy and neuropathy. Diabetic complications are the major cause of disability and death in diabetic patients. Apelin, a recently identified adipokine peptide, has been found to play important roles in diabetic complications. Here we summarize the current knowledge on the role of apelin in the pathogenesis of different diabetic complications. We also propose that similar to insulin resistance or leptin resistance, diabetics may also show apelin resistance. Potential clinical application of apelin and its analogue peptides in treating diabetic complications is discussed.

Keywords:

Apelin, adipokine, diabetes, diabetic complications, metabolic disorder, cardiomyopathy.

Affiliation:

Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, College of Life Sciences, Wuhan University, Wuhan 430072, Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030

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