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Immunogenicity in Protein and Peptide Based-Therapeutics: An Overview

[ Vol. 19 , Issue. 10 ]

Author(s):

L. Fernandez, R.H. Bustos*, C. Zapata, J. Garcia, E. Jauregui and G.M. Ashraf   Pages 958 - 971 ( 14 )

Abstract:


Currently it is well known that all biological drugs, including those with a fully human structure, are capable of inducing a host immune response known as immunogenicity [1]. The presence of ADAs can condition the drugĀ“s level and action, thus modifying the therapeutic effect and even the safety profile by its mechanism of action - neutralizing or non-neutralizing - and / or an increase in its clearance. Immunogenicity is a dynamic factor to be taken into account in biological therapy, especially in long-term treatments, and as a relevant aspect in the assessment of secondary response loss [2]. With the above, not only the knowledge but also the management of the immunogenicity of the different biological treatments, represent a useful instrument for optimization of the strategies of use for each drug, and in the design of predictive models of response, which finally permits a significant improvement in the efficacy and safety profile, aiming to a personalization of the therapies, especially in patients with autoimmune diseases, genetic disorders and cancer [3]. This review summarizes the events of immunogenicity that produce the biological drug, the factor that influence to immunogenicity and the assessment of immunogenicity.

Keywords:

Immunogenicity, biosensor, peptide, biological drugs, anti-drugs antibodies, ADAs.

Affiliation:

Evidence-Based Therapeutic Group, Clinical Pharmacology, Universidad de La Sabana, Chia, Evidence-Based Therapeutic Group, Clinical Pharmacology, Universidad de La Sabana, Chia, Evidence-Based Therapeutic Group, Clinical Pharmacology, Universidad de La Sabana, Chia, Evidence-Based Therapeutic Group, Clinical Pharmacology, Universidad de La Sabana, Chia, Riesgo de Fractura S.A.-CAYRE, King Fahd Medical Research Center, King Abdulaziz University, Jeddah

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